DESCRIPTION
D‑Ribose supports ATP energy production. D‑ribose is a simple carbohydrate that acts as a building block for many essential molecules in the human body. D‑ribose also helps to produce adenosine triphosphate (ATP), the primary source of energy used by all cells to maintain normal health and function. Every cell in the human body requires ATP for energy production. ATP levels in skeletal muscle can become severely depleted during and after certain types of exercise. Studies indicate that D‑ribose may support recovery after high‑intensity exercise. The maintenance of ATP levels is also important for cardiovascular health. D‑ribose has been shown in studies to support ATP recovery and function related to cardiac health. D‑ribose synthesizes adenine nucleotides, which are required by cardiac muscle and other tissue to make ATP. D‑ribose is ideal for athletes and individuals seeking cardiovascular health and energy support.
Available: 150g Powder
BENEFITS
- Supports healthy energy metabolism
- May support exercise performance and recovery
- Promotes cardiovascular health
- Promotes healthy cardiac cellular function
OVERVIEW
Ribose is essential for the synthesis of DNA and RNA, and it is responsible for the synthesis of NADPH. It is used to make ribose 5-phophate. It is the backbone of nicotinamide adenine dinucleotide (NAD). NAD is a critical cofactor for many redox reactions in the human body. It is also important for cell signaling, healthy metabolism, and cellular health. NAD may also help support a healthy aging process.
Athletic Performance
ATP levels in skeletal muscle can become severely depleted during and after certain types of exercise. Studies have shown that ATP recovery either through the adenine salvage pathway or de novo synthesis can take days. D‑ribose is an intermediate molecule in the PPP and purine nucleotide pathway and may increase phosphoribosyl pyrophosphate levels and adenine nucleotides, which may then accelerate the synthesis of ATP. A placebo‑controlled clinical trial assessed the impact of D‑ribose supplementation on delayed onset muscle soreness (DOMS) in college students. DOMS involves localized muscle soreness and tenderness that peaks from 24 to 72 hours post‑exercise and may be related to a response to inflammation and oxidative stress. Supplementation with D‑ribose occurred 1 hour before, 1 hour after, and 12, 24, and 36 hours after exercise. Muscle soreness and serum biomarkers were evaluated 1 hour before and 24 and 48 hours after exercise. Creatine kinase and lactate dehydrogenase were significantly higher in the placebo group 24 hours post‑exercise, but not in the D‑ribose group. Superoxide dismutase remained significantly elevated in the placebo group as compared to the D‑ribose group. Patient‑reported symptoms related to muscle soreness were also shown to improve in the treatment arm.
Dosing recommendations are given for typical use based on an average 150 pound healthy adult. Healthcare practitioners are encouraged to use clinical judgement with case‑specific dosing based on intended goals, subject body weight, medical history, and concomitant medication and supplement usage.
INGREDIENT BENEFITS
Cardiovascular Health
ATP provides energy for critical cardiac cellular functions. Conditions related to reduced blood flow or oxygenation can affect normal cellular production of energy compounds such as ATP. Depleted ATP levels can alter calcium balance in cardiac myocytes; calcium can remain fixed to troponin for a longer period of time in the diastole phase, which may result in diastolic dysfunction or changes in ventricular function.
In animal studies, supplementation with D‑ribose has been shown to elicit an increased rate of adenine nucleotide synthesis after ischemia. It has also been shown to improve recovery in myocardial ATP levels and functional recovery post‑ischemia.
D‑ribose was also shown to improve left ventricular contractility after acute myocardial infarction in murine populations. One animal study assessed the effect of supplementation with D‑ribose prior to infarction and found a significant reduction in the area of infarct and significant improvement in left ventricular function 6 hours after the cardiac event.
In clinical studies involving individuals with Class II‑III ischemic congestive heart failure (CHF), supplementation with D‑ribose has been shown to improve diastolic dysfunction and atrial contribution to left ventricular filling.
D‑ribose may also help individuals with Class II‑III CHF with left ventricular dysfunction improve ventilatory efficiency, maintain a maximal volume of oxygen, and improve quality of life parameters.
D‑ribose has been shown to support the body’s response to fatigue. A pilot study assessed the impact of supplementation with D‑ribose in 41 individuals with chronic fatigue syndrome or fibromyalgia. Participants took 15 g of D‑ribose daily until a 280 g bottle was finished (range, 17 to 35 days). While further research is required, significant improvements in energy levels, sleep patterns, mental clarity, pain threshold, and overall state of well‑being were reported.
ADDITIONAL INFORMATION
Suggested Use: Take 5 grams (approximately one scoop) per day or as directed by your health‑care practitioner.
Does Not Contain: Wheat, gluten, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, sugar, artificial sweeteners, or artificial preservatives.